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| 10 March | | |
| Sparta Prague | 1 - 1 | Lazio |
| Martin Frydek (13) | | Marco Parolo (38) |
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| Generali Arena | |
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| 10 March | | |
| Athletic Club | 1 - 0 | Valencia CF |
| Raul Garcia Escudero (20) | | |
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| San Mames | |
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| 10 March | | |
| Liverpool | 2 - 0 | Manchester United |
Daniel Sturridge (pen 20)
Roberto Firmino Barbosa de Oliveira (73) | | |
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| Anfield | |
|
| 10 March | | |
| Villarreal | 2 - 0 | Bayer 04 Leverkusen |
Cedric Bakambu (4)
Cedric Bakambu (56) | | |
|
| El Madrigal | |
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| 10 March | | |
| FC Basel | 0 - 0 | Sevilla |
| St Jakob-Park | |
|
| 10 March | | |
| Borussia Dortmund | 3 - 0 | Tottenham Hotspur |
Pierre-Emerick Aubameyang (30)
Marco Reus (61)
Marco Reus (70) | | |
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| Signal Iduna Park | |
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|
| 10 March | | |
| Fenerbahce | 1 - 0 | Sporting Braga |
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|
| Ulker Stadyumu | |
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| 10 March | | |
| Shakhtar Donetsk | 3 - 1 | RSC Anderlecht |
Taison Barcellos Freda (21)
Olexandr Kucher (24)
Eduardo Alves da Silva (79) | | Frank Acheampong (68) |
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| Arena Lviv | |
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